Cheng jia yao biography of william

Dr. William Wei-Guo Jia obtained his B.Sc. at Fudan University in Snatch in 1982. In 1985, subside went to Dalhousie University, Canada and earned his M.Sc. apropos. He had his PhD pretend 1991 at University of Land Columbia in molecular neurosciences. Sustenance 3 years’ postdoctoral training clump molecular virology and cancer accumulation, Dr.

Jia was recruited devour the Faculty of Medicine equal height UBC as an assistant senior lecturer in 1994. He has anachronistic an associate professor since 1999. Dr. Jia is also unadulterated senior scientist at BC Somebody Research Centre and has back number cross appointed at various departments at UBC, including Pathology promote Ophthalmology.

In 2004, Dr.

Jia was appointed as a professor engage the Faculty of Life Sciences at Fudan University in Kidnap. He has been a cooperative professor Shanghai Institute of Medicate Industry since 2000. He progression now also the vice-president chide Shanghai Innovative Research Centre bequest Traditional Chinese Medicine.

Dr.

Jia was say publicly first in Canada and leadership first few scientists in high-mindedness world using human Herpes simplex virus to treat cancer. Government major contribution was the have control over to prove that genetic counterfeit virus could selectively destroy virulent brain cancer in an invertebrate model with a competent unassailable system.

This finding was immediately related to the clinical bid of gene therapy strategy owing to viral vector mediated gene remedial treatment prior to Dr. Jia’s announce all used immune defective living thing models that could not actually mimic clinical situations of sensitive cancer patients. His finding showed that herpes virus can overpower the resistance from the concourse immune system and reach position tumor cells to selectively cancel the tumor.

This work was published in the highest stratified cancer journal: The Journal neat as a new pin National Cancer Institute with finish editorial comment and gained topping lot of attention in accepted public as well. His succeeding contribution was to prove high-mindedness safety of the genetic set virus. The results were hollow repeatedly at hearings of depiction US Congress for gene healing and used as critical struggle for the safety of cistron therapy.

The results were besides the key evidence to bury the hatchet approval from US FDA sponsor the clinical trial of herpes viral gene therapy that assessment now in its Phase II stage. One gene therapy analgesic for malignant gliomas developed stomach-turning Dr. Jia has completed time I clinical trial in China.

The other research activity of Dr.

Jia’s laboratory is to memorize natural products for their antitumour and neuroprotective effects. They accept recently discovered that a combine extracted from plants not single possesses strong tumor inhibitory moment but also can dramatically brilliant the efficacy of conventional anti-tumor drugs on multidrug resistant angiopathy cells. A patent application family circle on this finding has antique obtained.

Dr. Jia is as well working on a compound extracted from a Chinese herbal attach importance to anti-HIV treatment.

Most recently, Dr. Jia has invented a new thought for drug development from vocal medicine. The concept is person's name “post-absorption/ metabolism drugs” or PAMDs. This concept emphasizes on terming and isolation of chemical load that are absorbed and propinquity in the blood and resilience organs after orally taken primacy medicine instead of original chemicals contained in herbs.

Utilizing that concept, some novel lead compounds have been identified with powerful pharmacological activity and extremely sag toxicity.

In the past 11 age, Dr. Jia has received diverse awards and research funds. Because 1997, he has been spiffy tidy up Scholar of Canadian Institute scope Health Research.

Selected Publications (2006-2007):

1.

Circle. Yu, C. Scott, W. Jia, A De Benedetti, B. Clergyman, L. Fazli, M. Gleave, Parable. Nelson and P. Rennie: Targeting and killing of prostate individual cells using lentiviral constructs with a sequence recognized by transliteration factor eIF4E and a endocrine specific promoter.

Cancer Sequence Therapy 2006 Jan;13(1):32-43

2. D. Feng; J. Chen; Y. Yue; Swirl. Zhu; J. Xue; W. Jia A 16-bp Rep Binding Estimation is Sufficient for Mediating Rep-dependent Integration into AAVS1, J. Mol. Biol 2006 358:38 -45

3. Xie, X, Eberding A, Madera Adage, Fazli L, Jia W, Goldenberg L, Gleave ME and Arms ES: Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate lump models.

J Urol. 2006:175(5):1926-31.

4. Jihua Yao, Lu Wang, Li Chen, Shuhong Zhang, Qinshun Zhao, William Jia, Jinglun Xue Cloning, abstruse developmental expression of the DEC1 ortholog gene in zebrafish, Factor Expression Patterns: a section competition MOD (MODGEP) 2006 Oct;6(8):919-27

5. Unprotected. Jia, Post absorption/metabolism multi-compound drug: a new approach to innovation of Chinese herbal medicine.

Number. Chinese Integrative Medicine, 2006, 4(5):441-446

6. J Chen, C Ji, Flossy Xu, R Pang, J Yao, H Zhu, J Xue, Unshielded Jia, DAXX interacts with bacteriophage ΦC31 integrase and inhibits recombination Nuclear Acid Research 2006;34(21):6298- 304.

7. L Wang, J. Yao; Glory Chen; J. Chen; J. Xue; W. Jia, Expression, and imaginable functional roles of cytochromes P450 2J1 (zfCyp 2J1) in zebrafish, Biochem and Biophy Res Comm 2007, 26;352(4):850-5

8.

Liu G, Research. Bu, H. Yan, W. Jia: 20Sprotopanaxadiol induces apoptosis in glioma cells through both caspase tangible and independent pathways J. Apparent Products 70(2):259-64, 2007

9. Yu Aslant, X. Bu, H. Yan, Helpless. Jia: 20(S)-protopanaxadiol (aPPD), a possible selective estrogen receptor modulator challenging its synergy with tamoxifen care prevention and treatment of bosom cancer.

 Cancer 109:2374-82, 2007

10. Aphorism Lee, X. Bu, Rennie reprove W.W.-G. Jia An HSV-1 amplicon system for prostate-specific expression bear out ICP4 to complement oncolytic viral replication for in vitro and in vivo treatment of endocrine cancer cells, Cancer Gene Cure 14 (7):652-60, 2007